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S81450

Y-320

源葉(MedMol) 98%
  • 英文名:
  • 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxami
  • 別名:
  • CAS號:
  • 288250-47-5
  • 分子式:
  • C27H29ClN6O2
  • 分子量:
  • 505.01
  • 核磁/質(zhì)譜:
品牌貨號產(chǎn)品規(guī)格價格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計量單位 加入購物車...
源葉(MedMol) S81450-5mg 98% ¥285.00元 10 - - - EA 加入購物車
源葉(MedMol) S81450-10mg 98% ¥440.00元 10 - - - EA 加入購物車
源葉(MedMol) S81450-50mg 98% ¥1520.00元 7 - - - EA 加入購物車
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產(chǎn)品介紹

參考文獻

質(zhì)檢證書(COA)

摩爾濃度計算器

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  • 提示:詳情請下載說明書。
  • 產(chǎn)品描述:

    Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer

  • 靶點: IL-15;IL-17;ILReceptor;?Lipase;?Interleukin
  • 體內(nèi)研究:
    Y-320 (0-3 mg/kg; p.o.; daily, for 42 d) ameliorates collagen-induced arthritis (CIA) in DBA/1J mice with a reduction of IL-17 mRNA in arthritic joints. Y-320 (5 mg/kg; i.v.; every three days, for 18 d; Homozygous nude athymic mice with Bats-72 xenograft) sensitizes MDR xenograft tumor to Paclitaxel in vivo
  • 參考文獻:
    1. Ushio H, et, al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. 2. Hosseini-Farahabadi S, et, al. Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough. PLoS Biol. 2021 May 3;19(5):e3001221. 3. Hong J, et, al. Y-320, a novel immune-modulator, sensitizes multidrug-resistant tumors to chemotherapy. Am J Transl Res. 2020 Feb 15;12(2):551-562.
  • 溶解性: Soluble  in  DMSO
  • 保存條件: 2-8℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 1.98 ml 9.901 ml 19.802 ml
    5 mM 0.396 ml 1.98 ml 3.96 ml
    10 mM 0.198 ml 0.99 ml 1.98 ml
    50 mM 0.04 ml 0.198 ml 0.396 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。
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質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)


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