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S81429

COMPSTATIN

MedMol 98%
  • 英文名:
  • Compstatin
  • 別名:
  • H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond);H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2
  • CAS號(hào):
  • 206645-99-0
  • 分子式:
  • C66H99N23O17S2
  • 分子量:
  • 1550.78
品牌貨號(hào)產(chǎn)品規(guī)格價(jià)格(RMB) 庫(kù)存(上海) 北京 武漢 南京 數(shù)量計(jì)量單位 加入購(gòu)物車...
MedMol S81429-1mg 98% ¥400.00元 10 - - - EA 加入購(gòu)物車
MedMol S81429-5mg 98% ¥560.00元 10 - - - EA 加入購(gòu)物車
MedMol S81429-25mg 98% ¥1060.00元 5 - - - EA 加入購(gòu)物車
MedMol S81429-50mg 98% ¥1800.00元 6 - - - EA 加入購(gòu)物車
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參考文獻(xiàn)

質(zhì)檢證書(COA)

摩爾濃度計(jì)算器

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  • 提示:詳情請(qǐng)下載說明書。
  • 產(chǎn)品描述: Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans). Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively
  • 靶點(diǎn): Complement System;ComplementSystem
  • 體內(nèi)研究:
    Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures.Compstatin is stable in baboon plasma for more than 24 h. Pig xenografts survival is significantly longer in the Compstatin perfused group than in the control group
  • 參考文獻(xiàn):
    1. Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21. 2. Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65. 3. Bert J C Janssen, et al. Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem. 2007 Oct 5;282(40):29241-7. 4. A Sahu, et al. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. 1996 Jul 15;157(2):884-91.
  • 溶解性: H2O  :  100  mg/mL  (64.48  mM;  Need  ultrasonic)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 0.645 ml 3.224 ml 6.448 ml
    5 mM 0.129 ml 0.645 ml 1.29 ml
    10 mM 0.064 ml 0.322 ml 0.645 ml
    50 mM 0.013 ml 0.064 ml 0.129 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
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