歡迎光臨源葉生物,登錄 | 注冊(cè) |
當(dāng)前位置: 首頁 > 小分子抑制劑 > Autophagy > U0126-EtOH

瀏覽歷史

S81225

U0126-EtOH

源葉(MedMol) 98%
  • 英文名:
  • U0126-EtOH
  • 別名:
  • UO126 EtOH;(2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)succinonitrile,ethanol
  • CAS號(hào):
  • 1173097-76-1
  • 分子式:
  • C18H16N6S2.C2H6O
  • 分子量:
  • 426.56
  • 核磁/質(zhì)譜:
品牌貨號(hào)產(chǎn)品規(guī)格價(jià)格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計(jì)量單位 加入購(gòu)物車...
源葉(MedMol) S81225-5mg 98% ¥300.00元 >10 - - - EA 加入購(gòu)物車
源葉(MedMol) S81225-10mg 98% ¥500.00元 7 - - - EA 加入購(gòu)物車
源葉(MedMol) S81225-50mg 98% ¥1400.00元 >10 - - - EA 加入購(gòu)物車
源葉(MedMol) S81225-100mg 98% ¥2200.00元 5 - - - EA 加入購(gòu)物車
源葉(MedMol) S81225-400mg 98% ¥6500.00元 1 - - - EA 加入購(gòu)物車
大包裝詢價(jià)

提交您的電話號(hào)碼并同意《個(gè)人信息授權(quán)與保護(hù)申明》,到貨后將短信提示。
提交

產(chǎn)品介紹

參考文獻(xiàn)(1篇)

質(zhì)檢證書(COA)

摩爾濃度計(jì)算器

相關(guān)產(chǎn)品

  • 提示:詳情請(qǐng)下載說明書。
  • 產(chǎn)品描述: U0126 (U0126-EtOH) is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor
  • 靶點(diǎn): MEK2:60 nM (IC50);MEK1:70 nM (IC50);Mitophagy;?InfluenzaVirus;?MEK;?Autophagy
  • 體內(nèi)研究:
    Mice are treated daily with U0126-EtOH (U0126; i.p., 10.5 mg/kg). In control experiment, tumor sizes are constant or slightly increase all over the kinetic. At the opposite, in all U0126-EtOH experiments, engraftment and early tumor growth are significantly decreased. Furthermore, a 60-70% reduction in the volume of tumors treated with U0126-EtOH is obtained 9 days after injection and thereafter. Rats are subjected to 120 minutes transient middle cerebral artery occlusion (tMCAO) and thereafter treated with the U0126-EtOH (U0126; i.p., 30 mg/kg) at 0 and 24 hours of reperfusion. After treatment with U0126-EtOH, the vasoconstriction to S6c is markedly reduced
  • 參考文獻(xiàn):
    1. Favata MF, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32. 2. Droebner K, et al. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res. 2011, 92(2), 195-203. 3. Bessard A, et al. RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene. 2008 Sep 11;27(40):5315-25. 4. Ahnstedt H, et al. U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. J Cereb Blood Flow Metab. 2015 Mar;35(3):454-60.
  • 溶解性: DMSO  :  50  mg/mL  (117.22  mM;  Need  ultrasonic)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.344 ml 11.722 ml 23.443 ml
    5 mM 0.469 ml 2.344 ml 4.689 ml
    10 mM 0.234 ml 1.172 ml 2.344 ml
    50 mM 0.047 ml 0.234 ml 0.469 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
輸入產(chǎn)品批號(hào):

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:


質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)


  • =
    *
    *


源葉所有產(chǎn)品僅用作科學(xué)研究,銷售產(chǎn)品行為均適用于我司網(wǎng)上所列通用銷售條款。