S81207 |
MLN2480 |
源葉(MedMol) | ≥98% |
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- 產(chǎn)品描述: Tovorafenib (TAK-580, MLN 2480) is an orally active and selective inhibitor of pan-Raf kinase.
- 靶點: Raf
- 體內(nèi)研究:
Tovorafenib (TAK-580, MLN 2480) inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinical cancer models at concentrations that are tolerated in vivo. TAK-580 (MLN 2480) is most potent in BRAF mutant melanoma models but also has single agent activity in some RAS mutant models. The combination of MLN2480 with TAK-733 inhibits the growth of a broader range of RAS mutant tumor models than single agent TAK-580 (MLN 2480), including primary human tumor xenograft models of melanoma and CRC
- 參考文獻:
1. Elizabeth Grace Carideo Cunniff, et al. Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of
- 溶解性: Soluble in DMSO
- 保存條件: 避光;-20°C;干燥
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 1.975 ml 9.876 ml 19.752 ml 5 mM 0.395 ml 1.975 ml 3.95 ml 10 mM 0.198 ml 0.988 ml 1.975 ml 50 mM 0.04 ml 0.198 ml 0.395 ml
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輸入產(chǎn)品批號:
本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)