S81035 |
AZD8330 |
MedMol | 98% |
- 提示:詳情請(qǐng)下載說明書。
- 產(chǎn)品描述: AZD8330 (ARRY-424704) is a potent, uncompetitive MEK1/MEK2 inhibitor, with an IC50 of 7 nM.
- 靶點(diǎn): MEK1:7 nM (IC50);MEK2:7 nM (IC50);ERK;?MEK
- 體內(nèi)研究:
In tumour xenograft models, AZD8330 demonstrates dose-dependent tumour growth inhibition of approximately 90% at tolerated doses (1.0 mg/kg once daily [OD])
- 參考文獻(xiàn):
1. Cohen RB, et al. A phase I dose-finding, safety and tolerability study of AZD8330 in patients with advanced malignancies. Eur J Cancer. 2013 May;49(7):1521-9. 2. Baranski Z, et al. MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation. Genes Cancer. 2015 Nov;6(11-12):503-12.
- 溶解性: DMSO : ≥ 100 mg/mL (216.81 mM)
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.168 ml 10.841 ml 21.681 ml 5 mM 0.434 ml 2.168 ml 4.336 ml 10 mM 0.217 ml 1.084 ml 2.168 ml 50 mM 0.043 ml 0.217 ml 0.434 ml
- 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)