S80619 |
IMR-1 |
源葉(MedMol) | 99% |
- 提示:詳情請下載說明書。
- 產品描述: IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth
- 靶點: IC50: 26 nM (Notch);Gamma-secretase
- 體內研究:
IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models. Animal Model: Nude mouses with adenocarcinoma xenograft Dosage: 15mg/kg Administration: I.p.; for 28 days Result: Blocks tumor establishment.
- 參考文獻:
1. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
- 溶解性: soluble in DMSO
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 2.83 ml 14.148 ml 28.295 ml 5 mM 0.566 ml 2.83 ml 5.659 ml 10 mM 0.283 ml 1.415 ml 2.83 ml 50 mM 0.057 ml 0.283 ml 0.566 ml
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本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系,公式為:
質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)