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S80246

Sivelestat

源葉(MedMol) 98%
  • 英文名:
  • Sivelestat
  • 別名:
  • 西維來司他;N-[2-[[[4-(2,2-二甲基-1-氧代丙氧基)苯基]磺酰]氨基]苯甲酰]-(S)-甘氨酸;西維來司他鈉雜質;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid;n-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)
  • CAS號:
  • 127373-66-4
  • 分子式:
  • C20H22N2O7S
  • 分子量:
  • 434.463
  • 核磁/質譜:
品牌貨號產品規(guī)格價格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計量單位 加入購物車...
源葉(MedMol) S80246-5mg 98% ¥256.00元 4 - - - EA 加入購物車
源葉(MedMol) S80246-10mg 98% ¥472.00元 9 - - - EA 加入購物車
源葉(MedMol) S80246-50mg 98% ¥1600.00元 7 - - - EA 加入購物車
源葉(MedMol) S80246-100mg 98% ¥2800.00元 3 - - - EA 加入購物車
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參考文獻

質檢證書(COA)

摩爾濃度計算器

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  • 提示:詳情請下載說明書。
  • 產品描述: Sivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM.
  • 靶點: SARS-CoV;Serine Protease;SARS-CoV;SerineProtease
  • 體內研究:
    Administration of sivelestat attenuates pulmonary fibrosis after acute lung injury in mice. Sivelestat could attenuate sepsis-related kidney injury in rats. It blocks GAPDH/Siah1 which is a novel signaling pathway during the progression of spinal cord injury.
  • 細胞實驗: TMK-1 Gastric carcinoma cells are seeded into 96-well culture plates (5 ×103 cells/well) in RPMI containing 7% FBS, 2.0 mM L-glutamine, and 1% nonessential amino acids. Following 24-h incubation in RPMI-1640 medium with 5% FBS, the cells are incubated for 24, 48 or 72 h at 37°C in a humidified atmosphere of 5% CO2 with varied concentrations (0.1–1.0 μg/mL) of NE, or with varied concentrations (0.1–1000 μg/mL) of sivelestat or with concentrations (10 and 100 ng/mL) of anti-TGF-α antibody in the presence of 1 μg/mL NE. After incubation, 10 μL of MTT solution (5 mg/mL) is added to each well and the plates are then incubated for 3 h at 37°C. The growth medium is then replaced with 150 μL of dimethyl sulfoxide (Wako) per well and the absorbance at 540 nm is measured.
  • 動物實驗: Animal Models: Male Sprague-Dawley rats. Formulation: Saline. Dosages: 50 or 100 mg/kg. Administration: i.p.
  • 參考文獻:
    1.Li G, et al. Int J Mol Med. 2016, 38(3):767-75. 2.Huo J, et al. Neuroscience. 2016, 330:171-180. 3.Hagiwara S, et al. Inflamm Res. 2009, 58(4):198-203. 4.Wada Y, et al. Cancer Science. 2006, 97(10):1037-1043. 5.Araki Y, et al. Dig Dis Sci. 2011, 56(6):1672-81.
  • 溶解性: Ethanol:80  mg/mL  (184.1  mM)    H2O:<1  mg/mL    DMSO:80  mg/mL  (184.1  mM)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.302 ml 11.508 ml 23.017 ml
    5 mM 0.46 ml 2.302 ml 4.603 ml
    10 mM 0.23 ml 1.151 ml 2.302 ml
    50 mM 0.046 ml 0.23 ml 0.46 ml
  • 注意:部分產品我司僅能提供部分信息,我司不保證所提供信息的權威性,僅供客戶參考交流研究之用。
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本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系,公式為:


質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)


  • =
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