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S80203

LY2835219

源葉(MedMol) 99%
  • 英文名:
  • 2-Pyrimidinamine, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimida
  • 別名:
  • N-(5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine methanesulfonate; CS-1229; QCR-274;
  • CAS號:
  • 1231930-82-7
  • 分子式:
  • C27H32F2N8.CH4O3S
  • 分子量:
  • 602.7
  • 核磁/質(zhì)譜:
品牌貨號產(chǎn)品規(guī)格價(jià)格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計(jì)量單位 加入購物車...
源葉(MedMol) S80203-5mg 99% ¥112.00元 9 - - - EA 加入購物車
源葉(MedMol) S80203-10mg 99% ¥176.00元 10 - - - EA 加入購物車
源葉(MedMol) S80203-25mg 99% ¥344.00元 8 - - - EA 加入購物車
源葉(MedMol) S80203-50mg 99% ¥552.00元 5 - - - EA 加入購物車
源葉(MedMol) S80203-100mg 99% ¥784.00元 4 - - - EA 加入購物車
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參考文獻(xiàn)

質(zhì)檢證書(COA)

摩爾濃度計(jì)算器

相關(guān)產(chǎn)品

  • 提示:詳情請下載說明書。
  • 產(chǎn)品描述: Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively
  • 靶點(diǎn): Cdk4/cyclin D1:2 nM (IC50);CDK6/cyclinD1:10 nM (IC50);CDK2/cyclinE:504 nM (IC50);CDK9/cyclinT1:57 nM (IC50);CDK1/cyclinB1:1627 nM (IC50);CDK7/Mat1/cyclinH1:3910 nM (IC50);Cdk5/p25:355 nM (IC50);CDK5/p35:287 nM (IC50);PIM1:50 nM (IC50);PIM2:3400 nM (IC50);HIPK2:31 nM (IC50);DYRK2:61 nM (IC50);CK2:117 nM (IC50);GSK3b:192 nM (IC50);JNK3:389 nM (IC50);FLT3 (D835Y):403 nM (IC50);FLT3:3960 nM (IC50);DRAK1:659 nM (IC50);CDK
  • 體內(nèi)研究:
    Abemaciclib (LY2835219) (45 mg/kg, p.o.) in combination with RAD001 causes a cooperative antitumor effect in HNSCC xenograft tumor. Abemaciclib (LY2835219) (45 or 90 mg/kg, p.o.) shows significant tumor growth inhibition in an A375 xenograft model.
  • 參考文獻(xiàn):
    1. Ku BM, et al. The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma. Oncotarget. 2016 Mar 22;7(12):14803-13. 2. Yadav V, et al. The CDK4/6 inhibitor LY2835219 overcomes PLX4032 resistance resulting from MAPK reactivation and cyclin D1 upregulation. Mol Cancer Ther. 2014 Oct;13(10):2253-63. 3. Gelbert LM, et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with NSC 613327. Invest New Drugs. 2014 Oct;32(5):825-37. 4. Wu T, et al. Effect of abemaciclib (LY2835219) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo. Biochem Pharmacol. 2017 Jan 15;124:29-42.
  • 溶解性: H2O  :  125  mg/mL  (207.40  mM;  Need  ultrasonic)    DMSO  :  10  mg/mL  (16.59  mM;  ultrasonic  and  warming  and  heat  to  80°C)
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 1.659 ml 8.296 ml 16.592 ml
    5 mM 0.332 ml 1.659 ml 3.318 ml
    10 mM 0.166 ml 0.83 ml 1.659 ml
    50 mM 0.033 ml 0.166 ml 0.332 ml
  • 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
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