S80189 |
Faropenem sodium |
源葉(MedMol) | 98% |
- 提示:詳情請(qǐng)下載說(shuō)明書(shū)。
- 產(chǎn)品描述: Faropenem sodium是具有口服活性的β-內(nèi)酰胺抗生素,用于研究治療肺結(jié)核和社區(qū)獲得性肺炎的試驗(yàn)中。
- 靶點(diǎn): Antibacterial;Antibiotic
- 細(xì)胞實(shí)驗(yàn): Cell lines: RAW macrophages Concentrations: 7, 28, or 56 μg/ml Incubation Time: -- Method: RAW macrophages were grown in Dulbecco modified Eagle medium containing l-glutamine and sodium pyruvate (PAA Laboratories) supplemented with 10% fetal bovine serum. About 2.5 × 104 cells were seeded into each well of a 48-well plate and were infected with green fluorescent protein (GFP)-expressing M. tuberculosis (MTB_NDT1) at a multiplicity of infection (MOI) of 10:1 for 4 h. After infection, the monolayers were washed three times with fresh medium to remove nonadherent bacteria and then exposed to fresh medium with or without isoniazid (0.75 μg/ml), faropenem (7, 28, or 56 μg/ml), or meropenem (5, 25, or 50 μg/ml) plus clavulanate (2.5 μg/ml). Medium (containing antibiotics) was changed every 24 h. At various time points, macrophages were washed once with 1× PBS and then lysed using 0.5% Triton X-100. The macrophage lysates were diluted in PBS containing 0.05% Tween 80, serial dilutions were plated on 7H10 agar, a
- 動(dòng)物實(shí)驗(yàn): Animal Models: Adult female C57BL/6J mice Dosages: 500 mg/kg Administration: oral
- 參考文獻(xiàn):
1. Dhar N, et al. Antimicrob Agents Chemother. 2015, 59(2):1308-19.
- 溶解性: Soluble in DMSO、H2O
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 3.254 ml 16.271 ml 32.542 ml 5 mM 0.651 ml 3.254 ml 6.508 ml 10 mM 0.325 ml 1.627 ml 3.254 ml 50 mM 0.065 ml 0.325 ml 0.651 ml
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輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)