S80122 |
SNS-314 Mesylate |
源葉(MedMol) | 99% |
- 提示:詳情請(qǐng)下載說(shuō)明書(shū)。
- 產(chǎn)品描述: SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively
- 靶點(diǎn): Aurora A:9 nM (IC50);Aurora B:31 nM (IC50);Aurora C:6 nM (IC50);AuroraKinase
- 體內(nèi)研究:
In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off
- 參考文獻(xiàn):
1. Oslob JD, et al. Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4880-4. 2. Arbitrario JP, et al. SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.
- 溶解性: DMSO : 150 mg/mL (284.61 mM; Need ultrasonic)
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 1.897 ml 9.487 ml 18.974 ml 5 mM 0.379 ml 1.897 ml 3.795 ml 10 mM 0.19 ml 0.949 ml 1.897 ml 50 mM 0.038 ml 0.19 ml 0.379 ml
- 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
輸入產(chǎn)品批號(hào):
本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系,公式為:
質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)