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S41084

Raltitrexed

源葉(MedMol) ≥98%
  • 英文名:
  • (S)-2-(5-(methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic acid
  • 別名:
  • 雷替曲塞,D1694; ICID1694; ZD1694; ZD 1694; ZD-1694; TDX; brand name: Tomudex
  • CAS號:
  • 112887-68-0
  • 分子式:
  • C21H22N4O6S
  • 分子量:
  • 458.49
  • MDL:
  • MFCD12828867
  • 核磁/質(zhì)譜:
品牌貨號產(chǎn)品規(guī)格價格(RMB) 庫存(上海) 北京 武漢 南京 數(shù)量計量單位 加入購物車...
源葉(MedMol) S41084-10mg ≥98% ¥120.00元 6 1 - - EA 加入購物車
源葉(MedMol) S41084-100mg ≥98% ¥460.00元 7 1 - - EA 加入購物車
源葉(MedMol) S41084-1g ≥98% ¥1750.00元 預計交期:2-3天 - - - EA 加入購物車
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參考文獻

質(zhì)檢證書(COA)

摩爾濃度計算器

相關(guān)產(chǎn)品

  • 產(chǎn)品描述: Raltitrexed is an antimetabolite agent used in chemotherapy, acting by inhibiting thymidylate synthase
  • 靶點: Thymidylate Synthase;Nucleoside Antimetabolite/Analog;NucleosideAntimetabolite/Analog;DNA/RNASynthesis
  • 體外研究:
    Raltitrexed inhibits HepG2 proliferation by arresting the cell cycle at G0/G1, and the cell cycle is mediated via downregulation of cyclin A and CDK2. Raltitrexed (0.1, 0.5, 2.5 μg/mL) decreases the viability of SGC7901 cells in a dose- and time-dependent manner. Raltitrexed (0.5 μg/mL) shows typical apoptotic morphology, including nuclear shrinkage, fragmentation, chromatin condensation and apoptotic bodies in SGC7901 cells. Raltitrexed blocks the cell cycle at the G0/G1 phase, decreases in the mitochondrial membrane potential. Raltitrexed also increases the level of ROS, induces caspase-3-dependent apoptosis via activation of the mitochondria, and increases TS protein and mRNA expression levels. Raltitrexed (1.5 nM) reduces the number of GM00637 cells, selectively induces gene conversions, but does not affect DSB-induced HR or NHEJ.
  • 體內(nèi)研究:
    Raltitrexed (0, 5, 10, 11.5, 13.5, 15 mg/kg b/w, i.p.) increases the rates of resorbed embryos and growth retardation of murine model of NTDs in a dose dependent manner. Raltitrexed (11.5 mg/kg b/w) maximally inhibits the thymidylate synthase (TS) activity in embryonic tissue, decreases dTMP levels and while increases dUMP levels.
  • 參考文獻:
    1. Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23(5):237-48 2. Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398(1-2):223-31. 3. Xue S, et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10(4):1927-34. 4. Waldman BC, et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 1;7(10):1624-35.
  • 溶解性: Soluble  in  DMSO
  • 保存條件: -20℃
  • 配置溶液濃度參考:
    1mg 5mg 10mg
    1 mM 2.181 ml 10.905 ml 21.811 ml
    5 mM 0.436 ml 2.181 ml 4.362 ml
    10 mM 0.218 ml 1.091 ml 2.181 ml
    50 mM 0.044 ml 0.218 ml 0.436 ml
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